Most Medical Cannabis Claims Are Not Supported by Evidence
A December 2025 JAMA review synthesized the medical-cannabis evidence base through September 2025. The conclusion: most claimed therapeutic uses of medical cannabis are not supported by adequate clinical evidence. A small number of indications (notably certain pediatric seizure disorders treated with CBD-based pharmaceuticals like Epidiolex) do meet a clinical evidence bar; most others rest on small studies, anecdote, or industry marketing.
This is an uncomfortable finding for the broader medical-cannabis movement, but it's the current state of the evidence in the most credible medical journal in the world.
This page is a draft. The full writeup will list which indications the review concluded are supported, which are not, and what level of evidence each rests on.