Marijuana and Heart Disease
A May 2025 study in JAMA Cardiology found that both smoked marijuana and THC edibles were associated with impaired vascular function in otherwise healthy adults. The study specifically rules out the "edibles avoid the smoke so they're cardio-safe" assumption that's common among regular users — vascular impairment showed up across both routes.
Vascular dysfunction is an early step on the path to atherosclerosis, heart attack, and stroke. The mechanism appears to involve THC's direct effect on endothelial cells (the lining of blood vessels), independent of combustion products.
This page is a draft. The full writeup will cover the specific measurements, dose effects, whether quitting reverses the vascular damage, and how this compares to tobacco-induced vascular injury.